解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Brahma (BRM) is a novel anticancer gene, which is frequently inactivated in a variety of tumor types. Unlike many anticancer genes, BRM is not mutated, but rather epigenetically silenced. In addition, histone deacetylase complex (HDAC) inhibitors are known to reverse BRM silencing, but they also inactivate it via acet...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.613
更新日期:2014-01-30 00:00:00
abstract::Overexpression of the receptor tyrosine kinase ERBB2 (also known as HER2) occurs in around 15% of breast cancers and is driven by amplification of the ERBB2 gene. ERBB2 amplification is a marker of poor prognosis, and although anti-ERBB2-targeted therapies have shown significant clinical benefit, de novo and acquired ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.625
更新日期:2014-01-30 00:00:00
abstract::Targeted therapeutics are potential therapeutic agents because of their selectivity and efficacy against tumors resistant to conventional therapy. The goal of this study was to determine the comparative activity of monovalent, engineered anti-Her2/neu immunotoxins fused to recombinant gelonin (rGel) to the activity of...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.612
更新日期:2014-01-23 00:00:00
abstract::The phosphatidylinositol 3'-kinase (PI3K) pathway is dysregulated in multiple myeloma (MM); we therefore tested a highly selective class I PI3K inhibitor, GDC-0941, for anti-myeloma activity. Functional and mechanistic studies were first performed in MM cell lines, then extended to primary MM patient samples cultured ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.594
更新日期:2014-01-16 00:00:00
abstract::Low-grade glial neoplasms (astrocytomas) represent one of the most common brain tumors in the pediatric population. These tumors frequently form in the optic pathway (optic pathway gliomas, OPGs), especially in children with the neurofibromatosis type 1 (NF1)-inherited tumor predisposition syndrome. To model these tum...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.580
更新日期:2014-01-16 00:00:00
abstract::Stimulation of the c-Kit receptor tyrosine kinase has a critical role in the development and migration of melanocytes, and oncogenic c-Kit mutants contribute to the progression of some melanomas. c-Kit signalling activates the mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinase (PI3K) pathways an...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.562
更新日期:2014-01-09 00:00:00
abstract::Malignant peripheral nerve sheath tumors (MPNSTs) develop sporadically or in the context of neurofibromatosis type 1. Epidermal growth factor receptor (EGFR) overexpression has been implicated in MPNST formation, but its precise role and relevant signaling pathways remain unknown. We found that EGFR overexpression pro...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.579
更新日期:2014-01-09 00:00:00
abstract::BALB/c mice heterozygous for Trp53 develop a high proportion of spontaneous mammary tumors, a phenotype distinct from other mouse strains. BALB/c-Trp53+/- female mice, thus, resemble the hereditary Li-Fraumeni syndrome (LFS) characterized by early-onset of breast cancer, even though LFS involves TP53 mutations, which ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.38
更新日期:2013-11-28 00:00:00
abstract::The phosphatidylinositol 3' kinase (PI3K) pathway is involved in many cellular processes including cell proliferation, survival and glucose transport, and is implicated in various disease states, such as cancer and diabetes. Although there have been numerous studies dissecting the role of PI3K signaling in different c...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2013.44
更新日期:2013-11-21 00:00:00
abstract::B7-H4, a member of B7 family, is a transmembrane protein and inhibits T-cells immunity. However, in a variety of tumor cells, B7-H4 was detected predominantly in intracellular compartments with unknown mechanism and functions. In this study, we analyzed B7-H4 expression and subcellular distribution by immunohistochemi...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.600
更新日期:2013-11-14 00:00:00
abstract::Inflammation can act as a crucial mediator of epithelial-to-mesenchymal transition (EMT). In this study, we show that oncostatin M (OSM) is expressed in an autocrine/paracrine fashion in invasive breast carcinoma. OSM stimulation promotes spontaneous lung metastasis of MCF-7 xenografts in nude mice. A conspicuous epig...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.573
更新日期:2013-11-07 00:00:00
abstract::Interaction of tumour cells with their microenvironment impacts on all aspects of cancer, ranging from development through to treatment response. In this issue, Dvorak and colleagues(1) reveal a novel tumour/microenvironment relationship that may drive leukemia pathogenesis. Specifically, they find that leukemic cells...
journal_title:Oncogene
pub_type: 评论,杂志文章
doi:10.1038/onc.2012.639
更新日期:2013-10-31 00:00:00
abstract::The heterodimeric nuclear factor (NF) 90/NF45 complex (NF90/NF45) binds nucleic acids and is a multifunctional regulator of gene expression. Here we report that depletion of NF90/NF45 restores the expression of the p53 and p21 proteins in cervical carcinoma cells infected with high-risk human papillomaviruses (HPVs). ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.533
更新日期:2013-10-24 00:00:00
abstract::Adenoviruses are linear double-stranded DNA viruses that infect human and rodent cell lines, occasionally transform them and cause tumors in animal models. The host cell challenges the virus in multifaceted ways to restrain viral gene expression and DNA replication, and sometimes even eliminates the infected cells by ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.534
更新日期:2013-10-17 00:00:00
abstract::Plexin C1 is a type I transmembrane receptor with intrinsic R-Ras GTPase activity, which regulates cytoskeletal remodeling and adhesion in normal human melanocytes. Melanocytes are pigment-producing cells of the epidermis, precursors for melanoma, and express high levels of Plexin C1, which is lost in melanoma in vitr...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.511
更新日期:2013-10-10 00:00:00
abstract::Adhesion to the extracellular matrix (ECM) is critical for epithelial tissue homeostasis and function. ECM detachment induces metabolic stress and programmed cell death via anoikis. ECM-detached mammary epithelial cells are able to rapidly activate autophagy allowing for survival and an opportunity for re-attachment. ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.512
更新日期:2013-10-10 00:00:00
abstract::Cytokinesis is the final step of cell division. Increasing evidence suggests failure of cytokinesis might contribute to the development of cancer. Here, we demonstrate that the serologically defined colon cancer antigen-3 (SDCCAG3) forms a complex with PTPN13, a protein tyrosine phosphatase known to be involved in the...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.485
更新日期:2013-09-26 00:00:00
abstract::Chronic infection by hepatitis C virus (HCV) is a major risk factor for the onset and development of hepatocellular carcinoma (HCC), although the underlying mechanisms are unclear. The c-Myc oncogene contributes to the genesis of many types of cancers, including HCC, partly via the induction of genetic damage and the ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.484
更新日期:2013-09-26 00:00:00
abstract::Tumor cells typically contain a genome that is highly divergent from the genome of normal, non-transformed cells. This genetic divergence is caused by a number of distinct changes that the tumor cell acquires during its transformation from a normal cell into a tumorigenic counterpart. Changes to the genome include mut...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/onc.2012.576
更新日期:2013-09-19 00:00:00
abstract::KLF6, a ubiquitously expressed Krüppel-like transcription factor, is frequently inactivated in human cancer and has significant roles in cellular proliferation, apoptosis, differentiation and development. A key mechanism of KLF6-mediated growth suppression is through p53-independent transactivation of p21. Several can...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.457
更新日期:2013-09-19 00:00:00
abstract::Caveolin-1 (Cav1) is an integral membrane, scaffolding protein found in plasma membrane invaginations (caveolae). Cav1 regulates multiple cancer-associated processes. In breast cancer, a tumor suppressive role for Cav1 has been suggested; however, Cav1 is frequently overexpressed in aggressive breast cancer subtypes, ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.474
更新日期:2013-09-19 00:00:00
abstract::Thrombospondin-1 (TSP-1) is an endogenous inhibitor of angiogenesis whose expression suppresses tumor growth in vivo. Like many angiogenesis-related genes, TSP-1 expression is tightly controlled by various mechanisms, but there is little data regarding the contribution of post-transcriptional processing to this regula...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.464
更新日期:2013-09-12 00:00:00
abstract::Our recent study showed critical roles of Dmp1 as a sensor of oncogenic Ras, HER2/neu signaling and activation of the Arf-p53 pathway. To elucidate the role of human DMP1 (hDMP1) in breast cancer, one hundred and ten pairs of human breast cancer specimen were studied for the alterations of the hDMP1-ARF-Hdm2-p53 pathw...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.423
更新日期:2013-08-29 00:00:00
abstract::Ras oncogenes (Hras, Kras and Nras) are important drivers of carcinogenesis. However, tumors with Ras mutations often show loss of the corresponding wild-type (WT) allele, suggesting that proto-oncogenic forms of Ras can function as a suppressor of carcinogenesis. In vitro studies also suggest that WT Ras proteins can...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.404
更新日期:2013-08-22 00:00:00
abstract::Ewing sarcoma is a pediatric bone tumor characterized in 85% of cases by the fusion between EWS and FLI1 genes that results in the expression of the EWS-FLI1 aberrant transcription factor. Histologically, the Ewing tumor expresses high levels of the CD99 membrane glycoprotein. It has been recently described that CD99 ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.403
更新日期:2013-08-15 00:00:00
abstract::Cancer stem cells are believed to be responsible for tumor initiation and development. Much current research on human brain tumors is focused on the stem-like properties of glioblastoma stem cells (GSCs). However, little is known about the molecular mechanisms of cell cycle regulation that discriminate between GSCs an...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.399
更新日期:2013-08-15 00:00:00
abstract::Treatment options for adenoid cystic carcinoma (ACC) of the salivary gland, a slowly growing tumor with propensity for neuroinvasion and late recurrence, are limited to surgery and radiotherapy. Based on expression analysis performed on clinical specimens of salivary cancers, we identified in ACC expression of the neu...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.377
更新日期:2013-08-08 00:00:00
abstract::Persistent activation of the Abl tyrosine kinase in the BCR-ABL fusion protein is the major cause of chronic myeloid leukemia (CML). Among many other substrates BCR-ABL phosphorylates STAT5 and Src family kinases (SFK). Activated pSTAT5 is essential for initial transformation and maintenance of the disease. Cytokine-i...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.369
更新日期:2013-08-01 00:00:00
abstract::MicroRNAs (miRNAs), small non-coding RNAs that regulate gene expression post-transcriptionally, are involved in many complex cellular processes. Several miRNAs are differentially expressed in hematopoietic tissues and play important roles in normal differentiation, but, when aberrantly regulated, contribute to the abn...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.398
更新日期:2013-08-01 00:00:00
abstract::Proliferating cells need to produce a large amount of energy and, at the same time, need to maintain a constant supply of biosynthetic precursors of macromolecules that are used as building blocks for generating new cells. Indeed, many cancer cells undergo a switch from mitochondrial to glycolytic metabolism and displ...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/onc.2012.529
更新日期:2013-07-25 00:00:00
abstract::Small cell lung cancer (SCLC) is a disease characterized by aggressive clinical behavior and lack of effective therapy. Owing to its tendency for early dissemination, only a third of patients have limited-stage disease at the time of diagnosis. SCLC is thought to derive from pulmonary neuroendocrine cells. Although se...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.362
更新日期:2013-07-25 00:00:00
abstract::MEMO1 (mediator of ErbB2-driven cell motility 1) regulates HER2-dependent cell migration. Increased MEMO1 expression is associated with cancer aggressiveness. Here, we found that MEMO1 is also involved in breast carcinogenesis via regulating insulin-like growth factor-I receptor-dependent signaling events. We showed t...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.327
更新日期:2013-06-27 00:00:00
abstract::The tumor suppressor p53 has been found to be the most commonly mutated gene in human cancers; however, the frequency of p53 mutations varies from 10 to 70% across different cancer types. This variability can partly be explained by inactivating mechanisms aside from direct genomic polymorphisms. The p53 gene encodes 1...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.322
更新日期:2013-06-27 00:00:00
abstract::Chromatin remodeling proteins regulate multiple aspects of cell homeostasis, making them ideal candidates for misregulation in transformed cells. Here, we explore Sin3A, a member of the Sin3 family of proteins linked to tumorigenesis that are thought to regulate gene expression through their role as histone deacetylas...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.326
更新日期:2013-06-27 00:00:00
abstract::WEE1 kinase has been described as a major gate keeper at the G2 cell cycle checkpoint and to be involved in tumour progression in different malignant tumours. Here we analysed the expression levels of WEE1 in a series of melanoma patient samples and melanoma cell lines using immunoblotting, quantitative real-time PCR ...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.324
更新日期:2013-06-27 00:00:00
abstract::The signal transduction pathways, orchestrating the differentiation of hematopoietic stem and progenitor cells in response to cytokine stimulation, are strictly controlled by networks of feedback loops, highly selective protein interactions and finely tuned on/off switches. In hematological malignancies, the aberrant ...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/onc.2012.435
更新日期:2013-06-27 00:00:00
abstract::The recent years have seen a significant shift in the expectations for the therapeutic management of disseminated melanoma. The clinical success of BRAF targeted therapy suggests that long-term disease control may one day be a reality for genetically defined subgroups of melanoma patients. Despite this progress, few a...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/onc.2012.453
更新日期:2013-06-20 00:00:00
abstract::Chronic lymphocytic leukemia (CLL) is the most common leukemia in the Western world and remains incurable with conventional chemotherapy treatment approaches. CLL as a disease entity is defined by a relatively parsimonious set of diagnostic criteria and therefore likely constitutes an umbrella term for multiple relate...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/onc.2012.411
更新日期:2013-06-06 00:00:00
abstract::Mitochondria have been classically characterized as organelles with responsibility for cellular energy production in the form of ATP, but they are also the organelles through which apoptotic signaling occurs. Cell stress stimuli can result in outer membrane permeabilization, after which mitochondria release numerous p...
journal_title:Oncogene
pub_type: 杂志文章,评审
doi:10.1038/onc.2012.348
更新日期:2013-05-30 00:00:00
abstract::CD97, a member of the adhesion family of G-protein-coupled receptors (GPCRs), complexes with and potentiates lysophosphatidic acid (LPA) receptor signaling to the downstream effector RHOA. We show here that CD97 was expressed in a majority of thyroid cancers but not normal thyroid epithelium and that the level of CD97...
journal_title:Oncogene
pub_type: 杂志文章
doi:10.1038/onc.2012.301
更新日期:2013-05-30 00:00:00